16. He is one of the most hated men in history, despite _____ anything really bad.
(A) he didn’t do
(B) he hadn’t done
(C) not having done
(D) not done

despite 的用法

despite 為介系詞 (prep.)，意思為「儘管、雖然」。

1. despite＋N / Ving
*Monica went to school for the exam despite being sick.
雖然莫尼卡生病了，卻還是到學校考試。

*Despite the heavy rain, the Brown family still enjoyed the trip.
儘管下大雨，布朗一家人仍然很享受那趟旅行。

*Wendy wanted some desserts despite having eaten a lot of food. ?
儘管已經吃了一堆食物，溫蒂還是想再嚐一些甜點。
 
2. despite the fact that + S + V
*Benson insisted on joining the contest despite the fact that nobody supported him.
班森堅持要參加那項比賽，儘管沒有人支持他。

*Despite the fact that Kevin lost his left leg, he didn’t give up being a model.
儘管凱文失去了左腿，他卻沒有要放棄成為模特兒。

3. although/even though vs despite/in spite of
*although 和 even though 後面要接有「主詞」和「動詞」的完整小句子。例如：
We still enjoyed the concert although it rained.
（雖然下雨，我們還是很享受這場演唱會。)

*despite 和 in spite of 後面則會接一個「名詞」或「動名詞」。 例如：
We still enjoyed the concert despite the rain.
（雖然下雨，我們還是很享受這場演唱會。）

資料參考網址:
1. https://www.hopenglish.com/difference-between-although-and-despite
2. https://english.cool/despite/